Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-
A2ti-1
CAS: 570390-00-0
Molecular Formula: C20H22N4O2S
Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]- - Names and Identifiers
| Name | A2ti-1 |
| Synonyms | A2ti-1 Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]- |
| CAS | 570390-00-0 |
Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]- - Physico-chemical Properties
| Molecular Formula | C20H22N4O2S |
| Molar Mass | 382.48 |
| Storage Condition | -20°C，干燥，密封 |
| In vitro study | A2ti-1 (compound 1 b) is an annexin A2-S100A10 protein-protein interaction blocker. A2ti-1 (100 μM; for 72 hours) reduces HPV16 PsV infection of HeLa cells in a dose-dependent manner. A2ti-1 (10, 25, 50, 75, 100 μM; 24 hours) significantly reduces CFDA-SE-labelled HPV16 PsV entry into HeLa cells in a dose-dependent manner. Cell Viability Assay Cell Line: HeLa cells Concentration: 100 μM Incubation Time: For 72 hours Result: Reduced HPV16 PsV infection of HeLa cells in a dose-dependent manner with 100% inhibition of infection observed at 100 μM and similar results were observed in HaCaT cells. |
Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]- - Reference Information
| Biological activity | A2ti-1 is selective, high affinity annexin A2/S100A10 isotetramer (A2t) inhibitor, IC50 is 24 μM. A2ti-1 specifically disrupt the protein interaction between A2 and S100A10. A2ti-1 can prevent human papillomavirus type 16 (HPV16) infection. |
| target | IC50: 24 μM (A2t) |
| in vitro study | A2ti-1 (compound 1 B) is an annexin A2-S100A10 protein-protein interaction blocker. A2ti-1 (100 μ m; For 72 hours) reduces HPV16 PsV infection of HeLa cells in a dose-dependent manner. A2ti-1 (10, 25, 50, 75,100 μ m; 24 hours) significantly reduces CFDA-SE-labelled HPV16 PsV entry into HeLa cells in a dose-dependent manner. Cell Viability Assay Cell Line: HeLa cells Concentration: 100 μ M Incubation Time: For 72 hours Result: Reduced HPV16 PsV infection of HeLa cells in a dose-dependent manner with 100% inhibition of infection observed at 100 μ M and similar results were observed in HaT cells. |
| Cell Line: | HeLa cells |
| Concentration: | 100 μM |
| Incubation Time: | For 72 hours |
| Result: | Reduced HPV16 PsV infection of HeLa cells in a dose-dependent manner with 100% inhibition of infection observed at 100 μM and similar results were observed in HaCaT cells. |
Last Update：2024-04-09 21:54:55
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